Pharmacogenetics in drug development
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics and Pharmacogenomics : Applications in Drug Development and Therapeutics
Pharmacogenetics and pharmacogenomics is an emerging science that has a great application in drug development and therapeutics. It improves individualized therapy and gives crucial approach individuals with variability in drug response due to heredity thereby promotes personalized medicine. Pharmacogenomics intends to develop rational means of optimizing drug therapy, with respect to the patien...
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Drug hypersensitivity reactions and severe cutaneous adverse drug reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are examples of serious adverse drug reactions mediated through a combination of metabolic and immunological mechanisms that could traditionally not have been predicted based on the pharmacological characteristics of the drug alone. The discovery of new a...
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Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment can develop so called adverse drug reactions (ADRs) as a consequence of the treatment (cause over 100 000 deaths per year in USA). Pharmacogenetics is the discipline, which takes the patient’s genetic information of drug transporters, drug metabolising enzymes and drug receptors into account leadin...
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Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment can develop so called adverse drug reactions (ADRs) as a consequence of the treatment (cause over 100 000 deaths per year in USA). Pharmacogenetics is the discipline, which takes the patient’s genetic information of drug transporters, drug metabolising enzymes and drug receptors into account leadin...
متن کاملPharmacogenetics and adverse drug reactions.
Polymorphisms in the genes that code for drug-metabolising enzymes, drug transporters, drug receptors, and ion channels can affect an individual's risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual. Mutant alleles at a single gene locus are the best studied individual risk factors for adverse drug reactions, and include many genes coding for ...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2005
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2005.1688